H2N2V1, Main, Exploration, bibRecord, 001950

Influenza A Virus Neuraminidase: Regions of the Protein Potentially Involved in Virus–Host Interactions

Identifieur interne : 001950 ( Main/Exploration ); précédent : 001949; suivant : 001951

Influenza A Virus Neuraminidase: Regions of the Protein Potentially Involved in Virus–Host Interactions

Auteurs : Thomas G. Fanning ; Ann H. Reid ; Jeffery K. Taubenberger

Source :

Virology [ 0042-6822 ] ; 2000.

RBID : ISTEX:D32D53B3CF1BC61295BE796DAA7D8B8C6F9A4749

English descriptors

KwdEn :
- evolution, influenza A virus, neuraminidase, virus–host interaction.
Teeft :
- Acid sequences, Amino, Amino acid positions, Amino acids, Antigenic, Antigenic site, Antigenic sites, Clade, Coincident, Coincident regions, Colman, Forces institute, Glycosylation, Glycosylation sites, Hemagglutinin, Human clade, Influenza, Influenza virus neuraminidase, Maddison, Neuraminidase, Neuraminidase protein, Neuraminidase subtypes, Neuraminidases, Parsimony, Parsimony trees, Paup, Phylogenetic, Phylogenetically, Pirs, Protein conformation, Random trees, Subtype, Subtype neuraminidases, Subtypes, Taubenberger, Virol, Virology.

Abstract

Abstract: Phylogenetically informative amino acid positions (PIPs) were identified in influenza A neuraminidases of subtypes N1 and N2. Neuraminidase evolves in a lineage-specific way as the virus adapts to a new host or changes to evade the host's immune system. Thus, many PIPs undoubtedly identify positions involved in virus–host interactions. Phylogenetically important regions (PIRs) are defined as several PIPs near one another. There are 15 PIRs on N1 and 12 on N2, seven of which are shared between the two subtypes. Many PIRs are coincident with antigenic or glycosylation sites. Other PIRs may represent additional antigenic sites or may be involved in other aspects of virus–host biology.

Url:

https://api.istex.fr/ark:/67375/6H6-MQPW7JQQ-S/fulltext.pdf

DOI: 10.1006/viro.2000.0578

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000A78
to stream Istex, to step Curation: 000A78
to stream Istex, to step Checkpoint: 000765
to stream Main, to step Merge: 001993
to stream Main, to step Curation: 001950

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Phylogenetically informative amino acid positions (PIPs) were identified in influenza A neuraminidases of subtypes N1 and N2. Neuraminidase evolves in a lineage-specific way as the virus adapts to a new host or changes to evade the host's immune system. Thus, many PIPs undoubtedly identify positions involved in virus–host interactions. Phylogenetically important regions (PIRs) are defined as several PIPs near one another. There are 15 PIRs on N1 and 12 on N2, seven of which are shared between the two subtypes. Many PIRs are coincident with antigenic or glycosylation sites. Other PIRs may represent additional antigenic sites or may be involved in other aspects of virus–host biology.</div>
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Influenza A Virus Neuraminidase: Regions of the Protein Potentially Involved in Virus–Host Interactions

Influenza A Virus Neuraminidase: Regions of the Protein Potentially Involved in Virus–Host Interactions

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri